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apalutamide will minimize the extent or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicine that happen to be CYP3A4 substrates may result in lessen publicity to those drugs.Doses can be greater progressively as essen